The last Satoshis may never be mined

During the last Bitcoin reward era, the creation of new Bitcoins will consist of a single Satoshi every ten minutes.

If the reward is that low, then adding the coinbase transaction to the block may not be profitable for the miner, because it will occupy the space of another transaction which pays a higher fee. As so, those Satoshis may never get into circulation.

I assume this will occur way earlier than the last reward era. Whenever the block reward becomes lower than the equivalent in fees for the coinbase transaction, the miner would prefer not to create those new Sats.

Not necessarily a bad thing. Those Sats never put in circulation will very slightly increase scarcity. However, we may reach 0% inflation way earlier than we think.