What is the biggest threat to Bitcoin in 2022 and beyond?

I say it is too many people either being too lazy or too ignorant to control their own Bitcoins, trusting them to exchanges, who become de facto Bitcoin banks.

Bitcoin then loses its greatest feature, decentralization, becoming more and more centralized within a few exchanges, many of whom are already not working in Bitcoin's best interest (Coinbase), or are highly corruptible from external factors, like regulators and governments. Or vulnerable to outright theft, from hackers, or embezzlement from within.

If millions of Bitcoins are just in exchanges, then Bitcoin isn't really decentralized anymore. It's just a digital version of the banking system we already have, and are trying to get away from. If that is the case, we've all missed the point of Bitcoin.

So misuse of exchanges, turning them into de facto central banking centers, are Bitcoin's greatest threat, IMO.

What say you?